I used to shoot IHMSA Standing class (AA) with a .41 mag old model Ruger Blackhawk in the 70's. It had adjustable sights but I did'nt change the sights. I used different loads for the different ranges 170 Sierra with max 2400 @ 50, 100, 150 and 210 Sierra with max 2400 @ 200 yards. It helps to have a spotter and front sight and follow through were important. I shot at Reading and used to win regularly at Hopkington? (East of Brockton somewhere.) It was fun but ultimately, I switched to .22 as there were more shoots for them. Only offhand. Got to AAA standing and was 1979 State champ @ Framingham (then) Sportsman in standing. .22 was from 25 to 100 and there were more ranges that shot it. Last shoot was in RI in the 1990s. I had finally gotten a Contender .22 10" match in stainless. I had done all .22 up til then with a High Standard Victor. I had the zero off for the chickens with the contender but got 8/10 rams (offhand). I was pretty excited but they never had another shoot... Also, from a rest with a 2x scope, my XP100 in .221 fireball put three shots in 3/8" @ 200 yards. Long range pistol is a ball although my club is now limited to 100 yards.
Best shot was an empty 12 gauge shell standing up @ 100 yards with the Victor. I couldn't see it but it was at the intersection of the upright board and horizontal board on the target holder. Hit it dead center first time...