Do some research.
2” pipe and still around 1200fps.
Federal hst and you will stop and think about what you thought you were doing.
If the human tissue springs back undamaged because it was not touched by the bullet itself, then the only incapacitation is induced by what the bullet itself damages and possibly by a psychological reaction to getting shot. None of the practical concealed carry handgun calibers have enough velocity to cause significant damage with the temporary cavity. If the bullet damages the CNS, you will probably get some immediate effects with any caliber, if not incapacitation (spinal cord injury or brain stem), then at least confusion, though perhaps not be able to recall why they are trying to kill might not stop them from doing it. Otherwise, with an intact brain and spinal cord, your assailant will have 15-20 seconds at least to continue whatever they started before a blood pressure drop has any effect. Pumping the torso full of more bullets might cause the blood pressure drop to happen sooner, but you still have to wait for that event to occur unless you hit the CNS and incapacitate that way.
Personally, I think compliance is the most important factor, followed by competency of the shooter with that particular firearm. Need to have it, need to be able to hit something with it and also handle it safely every day.