Depends. If I'm in a hurry heading out the door I just slip my S&W 642 snubbie into a Mika pocket holster and scoot. Other times it's a Sig 229 .40 in either IWB or OWB holsters.
You know, in theory I liked the S&W 642. I bought it and found it was hard to keep accurate. It just has no barrel weight, so it didn't kick, but pivoted in my hand. If I can fire a .45 at 20 ft more accurate than .380 (no +P) that is a gun that doesn't work for me. Just my own personal opinion.