If you are shooting a standard NRA slow fire pistol target at 50 feet, the "black" includes the seven ring which has a 3.07 inch diameter:
50 foot slow fire -
50 yard Standard American reduced to 50 feet, 7, 8, 9 and 10 rings black. Target No. B-2.
10 ring .....................0.90 in
9 ring .......................1.54 in
8 ring .......................2.23 in
7 ring .......................3.07 in
6 ring .......................4.16 in
5 ring .......................5.56 in
4 ring .......................7.33 in
Which means that a six o'clock hold will result in the bullet hitting 1.5 inches higher than the point of aim if it hits a center "ten". Most shooters are going to practice defensive shooting at a closer range, like seven yards. This means that the bullet with a six o'clock hold will be even less than 1.5 inches above the point of hold.
I have seen many targets that NES members have posted/bragged about with six inch groups at 15 feet...
do you really think that the 1 to 1.5 inch difference between point of aim and point of impact matters?
I understand the dilemma because shooting at a round target with a six o'clock hold makes for a well defined point of aim but you want to get a good "score" so you get the gun to print a bit higher in the center of the black. There are two obvious solutions:
1. Using a round target, sight the gun to hit at the bottom of the black, hold at the bottom of the black. Be happy with a good group.
2. Don't use a round target, hold center, hit center.
An interesting problem with IHMSA targets back when we still shot them around here (with open sights) was that the targets are not symmetrical on either axis, up/ down, left/right.
For example, there is more "Turkey on the right of center, more "pig on the left.
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You will thank me for telling you that if you are defending against a squad of invading chickens, pigs, turkeys, and rams.
Pro tip
*:
1. If they are coming toward you, they are a whole lot narrower. You have to flank them to get a better shot.
2. They are a whole lot harder to see but easier to hit when you shoot the black side, not the fluorescent orange side.
* I will justify the use of the term as I took first place at the 1979 IHMSA Mass State Championship held at the Framingham Sportsmen club (now Dba Hopkinton Sportsman Association). I had the highest .22 offhand score. Small metal animals have feared me ever since...