Serious question - why the disdain for the manual safety? Maybe I'm old but many semi-auto pistols prior to striker fired had a similar safety. Once your used to swiping the manual safety, it becomes second nature. Kind of like throwing the safety to "off" on a rifle when you jump a deer in the woods - it's all one motion.
Its not a distain for manual safeties. Its a disdain for how most people are not willing to put the time in to actually train with one properly.
If you have a gun with a manual safety, you need to practice drawing and sweeping the safety off until it is 100% instinct.
I like to compete with both a 1911 and a Glock. And about once per year, I draw the 1911 and forget to sweep the safety off under the pressure of competition. (I also occasionally will sweep the nonexistant safety off my Glock)
Because of this failure, I won't carry a gun with a manual safety. Even though I practice with a manual safety PROPERLY, I still screw up about once per year because I also shoot striker fired guns without a manual safety.
I probably only see 1 in 10 people who carry manual safety guns practicing correctly.
Most get to the range, take their gun out of the holster, take the safety off. Clear it. Load a mag with practice ammo and shoot. Then they shoot 100 rounds, reload with their carry ammo, put the safety back on and leave.
In their entire range session, they drew from a holster (or came up from low ready if your club prohibits holster draw) and swiped off the safety exactly once. (!!!!) They swiped the safety on when they came off target exactly zero times.
They should have been practicing swiping the safety off EVERY TIME they came up on target. But instead, they were lazy and just left the safety off. Those people are completely UNPREPARED to use a manual safety gun in a defensive situation.
So unless you shoot only guns with manual safeties and can regularly practice properly, most are better served by a gun without a manual safety.
But what do I know. I'm too dumb to remember what gun I'm carrying.
Bottom line is that unless you are coming to the P365 from a 1911, spend the few extra bucks on the secondary market and buy one without a safety.