I've been shooting a Ruger MkIII 22/45 its been super reliable, no jams or misfires useing mainly bulk Federal 36g HPs. I have nothing bad to say about this gun, outside of "learning" the reassembly technique....which is a pain.
Cudos to the reassmebling procedure, once you have it down, it becomes second nature though, must have patience with it..... you will absolutely love the ruger MK series, I promise you...