AR thumper cal. - availability?

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I'm contemplating going for a big bore AR, or upper. Most likely, a 450 Bushmaster. I've yet to get the press running but plan to reload. Ballistics aside (as I'm only concerned with performance inside 200 yards), is the 450 Bushmaster a suitable candidate for reloading? Or, should I favor another caliber? I'm more concerned with component availability, over cost per round.
 
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