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What do you prefer about it? I've never held the HK 45c, so I can't comment it.
I have a full size USP 45 that I am quite happy with. I like the HK45, but can't fathom why it holds two fewer rounds. That is a big turn off for me.
The grip is the first and biggest thing. I don't know if just the side panels or also something about the front and back straps, but the USPc just feels better. It's boxier for sure, but my USPc is also way tighter than my 45c, and feels more solid, though that may just have something to do with the number of rounds through each.