If this is really a concern at all you shouldn't be carrying
any handgun, regardless of action type. That's why most people train to index their finger on the frame until they're ready to fire. Also, when is there ever a rush to holster a firearm? Never, really. Not to mention carrying an empty chamber is bad regardless of who makes the thing, although you seem to acknowledge that.
You're better off saying ""I just shoot better and am more comfortable with this gun" than making up poor excuses to legitimize the choice. There's a bunch of reasons why I can think of that someone might want to carry one of those guns (eg, like ergonomics, natural point of aim, or a long history of using DA/SA firearms and being proficient, and more comfortable with them- etc.) but "I'm too worried about shooting myself" is kinda mind numbing. If I felt that way about most serviceable handguns I probably wouldn't carry.
I'm intimately familiar with these brain diseases because I was partially infected with them at one time. I carried mostly hammer fired, nearly-all-metal handguns (P239, P226 were frequent carry choices) for the first couple years I carried. I didn't believe in handguns like Glocks, etc, or anything else that had a preloaded striker. Eventually I figured out that I was mentally retarded and added a Glock to the repetoire. The rest is history.
The P250 is not striker fired. It's a hammer fired, long-DAO, piece of dog meat that hopefully will get discontinued soon.
It also has a rail on it.
-Mike