The problem with the rimfire versions of the LCR is the ridiculously stiff trigger.
the .22 LR version has a much stiffer mainspring, necessary to reliably ignite rimfire rounds. This meant the trigger was MUCH heavier than centerfire versions of the LCR.
I had a woman student who had her carry license, but was having a hard time getting comfortable shooting.
The first time we met, I assessed her as being someone who had pretty good marksmanship skills but her gun handling was atrocious.
She was perhaps the least mechanically inclined person I've ever given instruction to. The answer to me was a revolver.
So I borrowed a Ruger LCR in 38 and she did ok. She had some trouble with recoil management, but I thought we could do better.
I was also able to borrow a .22 LR LCR and we tried that. I didn't know about the DA trigger. She had a hard time with that.
So we took a chance and ordered a .327 from an FFL friend as well as a larger hogue grip that allows her whole hand to fit on the grip.
When she shot the gun, it was a match made in heaven. The best in the business LCR double action trigger, combined with the large grip and low recoil of the .327 produced a very shootable gun that she loved.
The extra round over the .38 didn't hurt either.