Cool..
I found that if I follow the Lee instructions for setting the crimp die, it gets me to a good starting point. As for resetting your crimp, Once you have it set, you shouldn't have to change it much at all for different bullets. The Auto-Disk powder measure with the disks can be tricky, but there are a couple of things you can do.. First Lee makes the Micro-Disks, where you basically use 2 disks that are half as thick, and you just line up different holes to get a better range of powder drops. I almost bought these, until I found this baby.
http://www.midwayusa.com/eproductpage.exe/showproduct?saleitemid=150005
It gives you some directions to get you close to the charge you are looking for, but then you just fine tune it with the knob. Best $10 I spent!
As for shooting your first loads, just make sure you have all your safety gear on, if you're worried about it, gloves might make you feel better. If you shoot a round that doesn't feel right, STOP! Make your gun safe, and check that the chamber and barrel are free from obstructions, then continue.
We expect a full report after you get to the range.
Adam