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Yes.....and any one tangentially related to you (cousins, nieces, etc). The government is actively (and aggressively) using databases like these for law enforcement. Just ask the Golden State Killer:So, my younger sister had a test done because, she's stupid. Can a DNA company deduce from her results what my results would be like as we share the same parents?? s
Yes.....and any one tangentially related to you (cousins, notices, etc). The government is actively (and aggressively) using databases like these for law enforcement. Just ask the Golden State Killer:
The Golden State Killer Is Tracked Through a Thicket of DNA, and Experts Shudder
they can't map out your DNA from hers but if your DNA was left at a crime scene and they could upload it and run it against the database held by that company (like GEDMatch allows) it would should you as a "close match" and a full sibling to her (assuming you are). Then the possibilities are limited to who the DNA at the crime scene belongs to - you and your siblings.So, my younger sister had a test done because, she's stupid. Can a DNA company deduce from her results what my results would be like as we share the same parents??
I did find out through her results that I have WAY more Native American blood (well, "1st Nation" because my Great Grandmother, full blooded Iroquois, came from Canada) than granny warren does
That's more likely genetic DNA testing. 23andMe does that and companies that do specific testing for genetic disease that you go through your doctor to access but most of the DNA testing companies for genealogy purposes do not do genetic/health testing.That part is just stupid.
It is useful if your family has a history of some type of cancer, you can get tested to see if you too should be careful and take action now. I know a person who's mother had ovarian cancer, so she hurried, had kids and got everything removed because she had a high chance of also getting it.
If your family doesnt have a history of cancer or other diseases, then getting tested to find out if you might have a chance of getting something is plain stupid (from what I have been told by a few biologists and doctors). Apparently it is because the tests are not good when used in a generic way, they are good when targeting a specific disease.
My company now covers DNA testing, so I spoke with a few people about this and decided to not do it because it could cause more troubles than good. Not only by making me worry about stuff that might never happen, but also because it could potentially be used against me.
It doesn't have to be a family member like a sibling or parent. If enough of your 3rd cousins (or even 4th) test - you can be found. This is how the Golden State Killer was found. They figured out who his great great great grandparents were. When 2 people share 3xgreat grandparents, they are 4th cousins.Thankfully nobody in my family has done it,which would by proxy means i might as well do it.
Great lolIt doesn't have to be a family member like a sibling or parent. If enough of your 3rd cousins (or even 4th) test - you can be found. This is how the Golden State Killer was found. They figured out who his great great great grandparents were. When 2 people share 3xgreat grandparents, they are 4th cousins.
That is an amazing story!!!
Yes but do they take what they want and destroy your sample or do they keep it until someone with deep pockets (.gov) comes along to do the full sequence?I work in a biotech research lab. I’m a software guy, not a biologist, so my knowledge of the biotech stuff is fair at best, so take this with a grain of salt. My response is “meh”.
23andme doesn’t perform genome sequencing. Genome sequencing tries to sequence your entire genome. That is, it is an attempt to read out the entire string of 3 billion A’s, C’s, T’s, and G’s that make up your genome. But 23andme doesn’t do that because it is still too expensive.
23andme does array-based genotyping. That is, they have a chip that has an array of the complement of a bunch of genetic variations. They chop up your dna into fragments and wash them over the chip. If you have a particular variation, then a fragment with that variation binds to the chip at that location. This type of genotyping only tells you whether you have one of the variations on the chip. In contrast, whole genome sequencing will find all* your variations. Array-based genotyping is quick, cheap, and produces a manageable amount of data. Whole genome sequencing, in contrast, produces enormous amounts of data and requires very robust computational pipelines typically running in the cloud.
As for the data itself, making associations between genotype (that is, the presence of a variation) and a disease based solely on self-reported health data seems to me to be of dubious value. I hope GSK is not paying 23andme a lot to access this data.
There are a number of large scale biobank projects that are far more likely to produce useful results. These are creating very large cohorts, are using whole genome sequencing, AND they have access to medical records. Here in the US the All Of Us project is just starting with the goal of sequencing 1M people. The UK Biobank has recruited 500k donors.
As for the privacy issue, I expect that the agreement with GSK is giving them deidentified data and requiring them to not release the genotype data. I would be far more concerned with law enforcement gaining access to 23andme data than GSK data.
If I had done 23andme (I haven’t), this agreement wouldn’t get my panties in a twist.
* Yes, whole genome sequencing still doesn’t get the ENTIRE genome. Certain areas with large strings of repeats are still hard to sequence and align.
And, that was a choice. The above examples are notI have a weird genetic condition, Dupuytren's (du-pwe-TRANZ) contracture, that causes primarily your pinky and ring fingers to curve in but can also effect other fingers. I had extensive surgery to correct it and consider myself a lucky man.
It is linked to northern European white men and I volunteered to be part of a genetic study to research it. My Dad had it also and we both gave blood samples for DNA study. I understand the privacy concerns and they had reams of paper that said I'm protected but I wanted to do my part