Yes, you can definitely swap them out as needed. A more "fancy" single-stage presses, like my
Frankford Arsenal M-Press, allow you to swap dies quickly without resetting the die height adjustments. this is super valuable when you load multiple calibers on a single press. I use the same single-stage press to load 6.5 Creedmoor, 6.5 PRC, 6.5 Grendel, 40S&W, and 5.56. Thanks to the ability to swap dies, I can easily prepare for the weekend's rifle range activities in a matter of a few hours on Friday night
One thing most folks will tell you is that reloading is like Yoga: you get this Zen-like feeling that unwinds you from the week's stresses. The stress knots just melt away...