Yes, the caliber conversions, as people have argued over, cost between 100 and 200+ dollars for a 650. (not including dies, which are needed for any press)
Thats why I got the lee classic cast turret. For the cost of a turret ($10) plus dies, I can reload with reasonable speed all of my odd ball calibers. Its not fast, but with the auto index rod in place I can do better than 120 rounds per hour. For precision rifle calibers, I remove the index rod and use it like a single stage with quick change dies and heads. The turret has allowed me to load calibers that I don't shoot a lot of with out a huge investment. (.44 mag, .357 mag, .460 S&W mag)
I recently had the opportunity to swap for a Dillon 550 B. This may be the worlds most perfect press. Its nowhere near as fast as my 650s, but you can run a single shell around to test things or when working on developing loads.
I also have painted one of the shell plate stations yellow. I've experimented with making precision rifle ammo on it and when putting a case in the same shell plate position every time, the cartridge length is as consistent as my long since abandoned single stage or Lee turret. I'm thinking about a bearing upgrade for it.
Its funny. After spending a few weeks on the 550 working up loads for .300 blk and .380 (which, along with .223 all share the same shell plate), I jumped on my 650 last night to load up some 9mm. It is SOOOO much faster. At least for me. But with the auto index and the cases automatically dropping down, its definitely geared towards production, not experimentation.