I built a dedicated .22RF AR. Standard lower, with dedicated .22 RF barrel with .22 RF bolt adapter, which has a Redi-mag adapter that uses M&P 15-22 mags. The bolt catch works, holds open on last shot, and the forward assist works. So everything is set up like an AR. (and while I never used the forward assist on 5.56, it is very useful to get a .22RF round seated if the bolt doesn't quite go all the way forward which is sign it is time to clean / lube or try a different brand ammo)
I shoot it a lot, and I use it in Appleseed type training, where there is a time limit, and wasting time on mag changes is bad.
To answer your question, I have found that all the work with the .22RF at 25 yards (three position, timed shooting for accuracy, speed of mag changes) all translated to the ar - 15 at longer distances. Releasing empty mag, inserting full mag, releasing bolt catch, putting on/ off safety all became "no look" automatic actions. So for me, it all translated. Plus I tend to shoot the .22RF a LOT more.