I did have to re-zero, but I had put in adjustable rear sights at the same time and purchased the appropriate amount of magazines for that caliber and just stuck with that (.357 sig to .40)
Obviously if your going from something like .45 to 9mm or 9x25/ .38 super comp, you may have to do more...
Is that a 627?
I didn't realize there was a 5" version out there
And @allen-1 beat me to tk custom
One of those sites should have almost anything you need to gunsling.
I changed all my N frame sights to Dawson fronts. Easier...